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Testosterone (T) - 43.8 ng/dl and estradiol (E2) - 9.79 pg/ml. There was insignificant change in breast enlargement. Wt - 55.9 kg; Ht - 161 cm; body mass index - 21.6; no anosmia; SMR - G1P1, SPL - 4 cm.
After 1 month of therapy: T - 754.9 ng/dl; E2 - 28.5 pg/ml; T/E2 = 26.5:1.
The marked increased in T with letrozole in CDP as compared to lesser response in IHH can aid in distinguishing the two conditions with the use of AI.
Most of the recent studies with AI in boys and adult men do not show a major detrimental effects (including bone).
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It is questionable whether AI are able to stimulate T production sufficiently in men with truly low T levels.